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Investigation of risk factors for tonsillopharyngitis with macrolide resistant Streptococcus pyogenes in Turkish

Ergin Ciftçi1, Ulker Dogru, Haluk Güriz

  • 1Department of Pediatrics, Ankara University Medical School, Ankara, Turkey. erginciftci@doctor.com

Pediatrics International : Official Journal of the Japan Pediatric Society
|November 8, 2002
PubMed

Insights

Family macrolide antibiotic use is a significant risk factor for developing tonsillopharyngitis caused by macrolide-resistant Streptococcus pyogenes. Restricting macrolide use can help prevent resistant infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Streptococcus pyogenes is a primary cause of tonsillopharyngitis.
  • Penicillin is the preferred treatment, but macrolides are alternatives for allergic patients.
  • Increasing macrolide resistance in S. pyogenes necessitates investigation into risk factors.

Purpose of the Study:

  • To identify risk factors associated with tonsillopharyngitis caused by macrolide-resistant S. pyogenes.
  • To understand the development of antibiotic resistance in pediatric tonsillopharyngitis.

Main Methods:

  • Investigated 345 children diagnosed with S. pyogenes tonsillopharyngitis.
  • Assessed various potential risk factors for infection.
  • Determined antibiotic susceptibility of isolated S. pyogenes strains to erythromycin, clarithromycin, and azithromycin.

Main Results:

  • Macrolide resistance rates were 3.8% for erythromycin and 4.2% for clarithromycin and azithromycin.
  • Recent macrolide antibiotic use within the family (3 months) was a significant risk factor (OR=7.04, P=0.005).
  • Identified family macrolide exposure as a key predictor of resistant S. pyogenes infections.

Conclusions:

  • Limiting macrolide antibiotic consumption is crucial for preventing tonsillopharyngitis due to macrolide-resistant S. pyogenes.
  • This finding supports antimicrobial stewardship programs to combat antibiotic resistance.
  • Further research into resistance mechanisms and broader public health interventions is warranted.
Abstract

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