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[Chronic Chlamydia pneumoniae infection in patients with coronary disease. Relation with increased fibrinogen values]

Consuelo Fernández-Miranda1, Manuel Paz, José Luis Aranda

  • 1Servicio de Medicina Interna, Unidad de Lípidos y Aterosclerosis, Hospital Universitario 12 de Octubre, Madrid, Spain. cfmiranda@inicia.es

Medicina Clinica
|November 8, 2002
PubMed

Insights

Chronic Chlamydia pneumoniae infection is highly prevalent in Spanish coronary disease patients. This infection is linked to higher fibrinogen levels, a key cardiovascular risk factor.

Area of Science:

  • Infectious Disease Epidemiology
  • Cardiovascular Medicine
  • Immunology

Context:

  • Atherosclerosis development is potentially linked to Chlamydia pneumoniae infections.
  • Understanding chronic infection prevalence in coronary disease patients is crucial for risk assessment.

Purpose:

  • To determine the prevalence of chronic Chlamydia pneumoniae infection in Spanish patients with coronary disease.
  • To investigate the association between chronic C. pneumoniae infection and inflammatory markers and cardiovascular risk factors.

Summary:

  • The study found a high seropositivity rate for Chlamydia pneumoniae (72.8%) in Spanish coronary disease patients.
  • While general cardiovascular risk factors were similar, seropositive patients exhibited higher rates of hyperfibrinogenemia.
  • Multivariate analysis revealed a significant association between C. pneumoniae seropositivity and elevated fibrinogen levels (OR=2.42).

Impact:

  • Highlights the significant prevalence of chronic Chlamydia pneumoniae infection in patients with coronary artery disease.
  • Identifies hyperfibrinogenemia as a key inflammatory marker associated with chronic C. pneumoniae infection in this population.
  • Provides evidence supporting the role of C. pneumoniae in cardiovascular disease pathogenesis, particularly concerning fibrinogen levels.
Abstract

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