High altitude pulmonary edema. A rare disease?

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Updated: Jul 10, 2026

Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation
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Published on: November 21, 2023

J P Kleiner, W P Nelson

    JAMA
    |November 3, 1975
    PubMed

    Since its original description in the English literature 15 years ago, high altitude pulmonary edema (HAPE) has been the subject of many reports. The clinical and hemodynamic features of HAPE are now well recognized, but its underlying pathophysiology remains unclear. In this article, a case of HAPE is described and the clinical features, proposed pathogenesis, and treatment are discussed. (JAMA 234:491-495, 1975).

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