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Saliva, Salivary Gland, and Hemolymph Collection from Ixodes scapularis Ticks
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Published on: February 21, 2012

Cephalexin-related nephropathy.

S Verma, E Kieff

    JAMA
    |November 10, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Cephalexin and probenecid can cause hematuria and eosinophilia in patients with bacterial endocarditis. Discontinuing the medication promptly resolved these adverse effects, indicating a potential drug-induced reaction.

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    Area of Science:

    • Pharmacology
    • Nephrology
    • Infectious Diseases

    Background:

    • Bacterial endocarditis requires effective antibiotic treatment.
    • Cephalexin is a commonly prescribed oral cephalosporin antibiotic.
    • Probenecid is often used to increase antibiotic levels.

    Observation:

    • Two patients with bacterial endocarditis developed hematuria and eosinophilia.
    • These symptoms occurred during oral cephalexin and probenecid therapy.
    • Both patients had a history of penicillin allergy and prior intravenous cephalexin use.

    Findings:

    • Concurrent transient increase in serum creatinine was noted in one patient.
    • All observed abnormalities resolved after discontinuing cephalexin and probenecid.
    • This suggests a potential adverse drug reaction to the combination therapy.

    Implications:

    • Clinicians should be aware of potential cephalexin-probenecid adverse effects.
    • Monitoring for hematuria and eosinophilia is recommended in patients on this regimen.
    • Further investigation into the mechanism of this adverse reaction may be warranted.