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Relapsed non-Hodgkin's lymphoma diagnosed by flexible bronchoscopy
Shruti M Phadke1, Barbara A Chini, Donna Patton
1Division of Pulmonology, Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15116, USA.
Pediatric Pulmonology
|November 8, 2002
Summary
Pediatric non-Hodgkin's lymphoma (NHL) relapsed in the lungs of a 10-year-old girl. Diagnosis was confirmed via bronchoalveolar lavage and transbronchial biopsy, identifying CD30-positive cells and the t(2;5) translocation.
Area of Science:
- Pediatric Oncology
- Pulmonary Medicine
- Hematology
Background:
- Non-Hodgkin's lymphoma (NHL) can present with extranodal relapse.
- Pulmonary involvement in pediatric NHL requires accurate diagnostic methods.
Observation:
- A 10-year-old girl experienced pulmonary relapse of NHL, manifesting as cough, hemoptysis, and chest tightness.
- Diagnostic procedures included bronchoalveolar lavage (BAL) and transbronchial biopsy (TBB).
Findings:
- BAL and TBB identified malignant Ki-1 (CD30) anaplastic large-cell lymphoma cells.
- The characteristic t(2;5) chromosomal translocation was detected in the malignant cells.
- These minimally invasive techniques confirmed the diagnosis, obviating the need for open lung biopsy.
Implications:
- Bronchoalveolar lavage and transbronchial biopsy are effective for diagnosing pulmonary relapse of CD30-positive anaplastic large-cell lymphoma in children.
- Minimally invasive diagnostic approaches can improve patient outcomes and reduce procedural risks.
- Early and accurate diagnosis is crucial for timely therapeutic intervention in pediatric NHL relapse.