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Updated: Sep 28, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film
Published on: December 13, 2024
[Fibrin-collagen substance as a vehicle for local application of antibacterial agents]
V A Gorskiĭ1, A A Gertsog, I V Leonenko
1Russian State Medical University, Municipal Clinical Hospital No. 55, Moscow.
Abstract:
Inhibitory activity of fibrin-collagen substance (FCS) impregnated by various antibacterial agents against various microorganisms was investigated. It was demonstrated that antibacterials bind well with FCS, providing its sufficient antibacterial activity. Determination of growth-inhibition zones showed that antibacterial agents diffuse into medium well and demonstrated the same activity as discs with antibiotics. For clinical practice it is recommended to use for impregnation the following drugs: gentamycin, meropenem, cefriaxone and ciprofloxacin.
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