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Updated: Sep 28, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
[Clinical-therapeutic features of gynecomastia]
R Gabriele1, M Borghese, M Conte
1Dipartimento Chirurgia P. Valdoni, Università degli Studi La Sapienza di Roma.
Abstract:
This study reports 36 cases of gynaecomastia surgically treated. The median age was 25-years old (range 14-65 years). In 27 patients (75%) gynaecomastia was bilateral, in the others only one breast was interested. According to Simon's classification; 12 patients with stage 1, 18 stage 2a, 3 stage 2b and 3 stage 3 were observed. A specific cause was discovered in 12 cases: 2 Klinefelter syndrome and 10 adipomastia. Other 24 cases had an idiopathic origin. Subcutaneous mastectomy, through inferior periareolar approach was performed to all patients while submammary approach was reserved in selected patients (stage 3).
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