Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current concepts in multiple sclerosis: Part I.

Linda J Hanson1, William A Cafruny

  • 1USD School of Medicine, Vermillion, SD, USA.

South Dakota Journal of Medicine
|November 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Suppression of acute anti-friend virus CD8+ T-cell responses by coinfection with lactate dehydrogenase-elevating virus.

Journal of virology·2007
Same author

Porcine reproductive and respiratory syndrome virus (PRRSV) infection spreads by cell-to-cell transfer in cultured MARC-145 cells, is dependent on an intact cytoskeleton, and is suppressed by drug-targeting of cell permissiveness to virus infection.

Virology journal·2006
Same author

Polyclonal hypergammaglobulinemia and formation of hydrophobic immune complexes in porcine reproductive and respiratory syndrome virus-infected and uninfected pigs.

Viral immunology·2005
Same author

Lactate dehydrogenase-elevating virus induces apoptosis in cultured macrophages and in spinal cords of C58 mice coincident with onset of murine amyotrophic lateral sclerosis.

Virus research·2004
Same author

Hydrophobic IgG-containing immune complexes in the plasma of autoimmune MRL/lpr mice, lactate dehydrogenase-elevating virus-infected mice, and pigs: association with transforming growth factor-beta and pH-dependent amplification.

Viral immunology·2004
Same author

Glucocorticoid regulation of lactate dehydrogenase-elevating virus replication in macrophages.

Virus research·2003
Same journal

Idiopathic pure red cell aplasia: case report with review of literature.

South Dakota journal of medicine·2006
Same journal

Use of cold-adapted live attenuated influenza vaccine in pediatric patients.

South Dakota journal of medicine·2006
Same journal

Hope.

South Dakota journal of medicine·2006
Same journal

AMA and SDSMA: together, we are stronger.

South Dakota journal of medicine·2006
Same journal

Acute immune thrombocytopenic purpura in children and adolescents in South Dakota 1998-2004.

South Dakota journal of medicine·2006
Same journal

Medication-induced fever.

South Dakota journal of medicine·2006
See all related articles

Multiple sclerosis (MS) is an autoimmune disease potentially triggered by viral infections in genetically susceptible individuals. Research explores viral causes and genetic interactions to develop future vaccines and improved immunomodulation therapies for MS.

Area of Science:

  • Neuroimmunology
  • Autoimmune Diseases
  • Central Nervous System Disorders

Background:

  • Multiple sclerosis (MS) is a prevalent autoimmune disorder affecting the central nervous system, impacting about 0.1% of the US population.
  • Current evidence suggests viral infections may initiate autoimmune responses against nerve cells in genetically predisposed individuals.
  • The disease course is characterized by variable neurological deficits, remissions, and relapses.

Purpose of the Study:

  • To investigate the potential viral triggers of multiple sclerosis.
  • To understand the interplay between host genetics and immunopathogenic mechanisms in MS.
  • To explore future therapeutic strategies including vaccination and refined immunomodulation.

Main Methods:

  • Review of existing evidence on viral triggers and genetic susceptibility in MS.

Related Experiment Videos

  • Analysis of immunopathogenic mechanisms underlying autoimmune attacks on nerve cells.
  • Exploration of current and future therapeutic interventions.

    • Main Results:

    • Partial treatment success observed with immunomodulating agents like interferon-beta and intravenous immunoglobulins.
    • Ongoing research focuses on identifying specific viral etiologies and genetic factors contributing to MS.
    • The interaction between genetic predisposition and immune responses is a key area of investigation.

    Conclusions:

    • Understanding the complex interplay of viral infections, host genetics, and immune responses is crucial for MS pathogenesis.
    • Future research holds promise for developing preventative strategies, such as vaccines for susceptible individuals.
    • Refinement of immunomodulation therapies is expected to improve treatment outcomes for multiple sclerosis patients.