Related Experiment Videos
A chiral A2 B2 macrocyclic minireceptor with extreme enantioselectivity
Francesco Gasparrini1, Domenico Misiti, Marco Pierini
1Dipartimento di Studi di Chimica e Tecnologia, Sostanze Biologicamente Attive Università degli Studi La Sapienza, P.le A. Moro 5, 00185 Rome, Italy.
Organic Letters
|November 9, 2002
Abstract:
We describe a novel macrocyclic minireceptor that is assembled from a chiral 1,2-diamine and 5-allyloxyisophthalic acid. After immobilization on HPLC silica, the chiral macrocycle preferentially binds the L-enantiomers of simple amino acid derivatives, with enantioselectivities values up to 3.0 kcal/mol. [structure: see text]