Diterpenoids from cultured Erythropodium caribaeorum
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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Orazio Taglialatela-Scafati1, Urmila Deo-Jangra, Martha Campbell
1Department of Chemistry, University of British Columbia, Vancouver, B.C. V6T 1Z1, Canada.
Abstract:
The known antimitotic agent eleutherobin and the briarane diterpenoids erythrolides A and B have been isolated from cultured specimens of Erythropodium caribaeorum in amounts comparable to those reported from wild-harvested reef animals. The novel diterpenoid aquariolide A, having an unprecedented highly rearranged carbon skeleton (named aquariane), has also been found. The aquariane skeleton can be formally derived from the briarane skeleton by sequential di-pi-methane and vinyl-cyclopropane rearrangements. [structure: see text]
