Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Docetaxel-induced nail dystrophy.

Jenny Nicolopoulos1, Anne Howard

  • 1Department of Dermatology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.

The Australasian Journal of Dermatology
|November 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generalised granuloma annulare following ustekinumab therapy for palmoplantar psoriasis.

BMJ case reports·2025
Same author

Lisdexamfetamine-Induced Angioedema and Leukocytoclastic Vasculitis: A Case Report.

The Australasian journal of dermatology·2025
Same author

Buerger's Disease: Successful Management of Acute Cutaneous Features and Achieving Disease Remission With Pentoxifylline.

The Australasian journal of dermatology·2025
Same author

General dermatology.

Clinical and experimental dermatology·2025
Same author

Formulation and systemic therapy.

Clinical and experimental dermatology·2024
Same author

Use of bimekizumab to treat palmoplantar psoriasis in a patient receiving treatment for disseminated tuberculosis: a case report.

Clinical and experimental dermatology·2024
Same journal

Benzalkonium Chloride in Eye Drops Causing Allergic Contact Dermatitis: A Case Series.

The Australasian journal of dermatology·2026
Same journal

The Dermatologist's Role in Early PMOS Diagnosis.

The Australasian journal of dermatology·2026
Same journal

From Curriculum Variation to Clinical Capability: Advancing Dermatology Education in Australia.

The Australasian journal of dermatology·2026
Same journal

Fatal Phenobarbital-Associated Toxic Epidermal Necrolysis With Severe Acute Kidney Injury and Multiorgan Failure: Prognostic Value of SCORTEN and ALDEN.

The Australasian journal of dermatology·2026
Same journal

Granulomatous Vasculitis: An Unusual Manifestation of Metastatic Crohn's Disease.

The Australasian journal of dermatology·2026
Same journal

The Rintala Advanced Modification (RAM) Flap: A Novel Technique for Off-Centre Nasal Reconstruction.

The Australasian journal of dermatology·2026
See all related articles

Docetaxel chemotherapy can cause severe nail damage, including abscesses, in prostate cancer patients. Prompt medical intervention and continued treatment are often successful, with nail conditions typically resolving.

Area of Science:

  • Oncology
  • Dermatology
  • Pharmacology

Background:

  • Metastatic prostate cancer treatment often involves chemotherapy agents like docetaxel.
  • Docetaxel-induced nail changes are a recognized adverse effect, impacting 30-40% of patients.

Observation:

  • A 73-year-old man on docetaxel developed acute fingernail dystrophy, including onycholysis, subungual hemorrhage, and paronychia.
  • The condition progressed to a subungual abscess requiring nail plate avulsion and fenestration for drainage.
  • Subungual pus collections (onychophosis) were observed, with cultures yielding mixed organisms.

Findings:

  • The patient's nail dystrophy was a severe adverse reaction to docetaxel chemotherapy.
  • Surgical decompression and drainage of the abscess were necessary interventions.

Related Experiment Videos

  • Cultures suggested potential secondary bacterial infection, possibly influenced by prior antibiotic use.

    • Implications:

    • Severe nail changes, though common with docetaxel, may require specific management strategies.
    • Discontinuation of docetaxel is not always necessary for mild to moderate nail toxicity.
    • This case highlights the importance of recognizing and managing severe iatrogenic nail conditions in cancer patients.