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Published on: December 27, 2013
Vancomycin encapsulation in biodegradable poly(epsilon-caprolactone) microparticles for bone implantation. Influence
A-M Le Ray1, S Chiffoleau, P Iooss
1Laboratoire de Pharmacie Galénique, Centre de Recherche sur les Matériaux d'intérêt Biologique, Equipe INSERM 99-03, BP84215, 44042 Nantes cedex, France.
Abstract:
Vancomycin encapsulation in biodegradable poly(epsilon-caprolactone) microparticles (200 microm mean diameter) was most efficient with a simple emulsion technique that dispersed 122.5 mg/g of polymer. Scanning electron micrographs showed smooth or pitted particles. Dissolution studies were correlated with microparticle morphology, indicating higher release with pitted particles when vancomycin was encapsulated in a dissolved state. The cytocompatibility of these poly(epsilon-caprolactone) microparticles was demonstrated by a direct contact cytotoxic assay. This material can be considered as an efficient drug delivery system for bone implantation.
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