Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cold hibernated elastic memory foams for endovascular interventions.

Annick Metcalfe1, Anne-Cécile Desfaits, Igor Salazkin

  • 1Interventional Neuroradiology Laboratory, CHUM Research Center, Notre-Dame Hospital, Mailloux Pavilion M-8206, 1560 Sherbrooke East, Montreal, Que, Canada H2L 4M1. annick.metcalfe@polymtl.ca

Biomaterials
|November 9, 2002
PubMed
Summary

Cold hibernated elastic memory (CHEM) foam shows promise for medical uses. This shape memory polymer effectively occluded arteries in dogs, indicating potential for new endovascular devices.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stereotactic Radiosurgery for Brain Arteriovenous Malformations as Expected Curative Treatment: Outcomes of Patients Included in the Prospective Registry of a Pragmatic Trial.

World neurosurgery·2026
Same author

Delphi Consensus on Early Neurologic Improvement after Mechanical Thrombectomy.

AJNR. American journal of neuroradiology·2026
Same author

Understanding statistical versus clinical significance: a critical appraisal of the CREST-2 study.

Neuro-Chirurgie·2026
Same author

Response to the comments by Cavalcante et al. regarding our article entitled "Understanding non-inferiority trials: Lessons from trials comparing thrombectomy with or without intravenous thrombolysis."

Neuro-Chirurgie·2026
Same author

Current Opinions on Optimal Management of Basilar Artery Occlusion: After the BEST of BASICS Survey.

Stroke (Hoboken, N.J.)·2026
Same author

Late Window Imaging Selection for Endovascular Therapy of Large Vessel Occlusion Stroke: An International Survey.

Stroke (Hoboken, N.J.)·2026

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Engineering

Background:

  • Cold hibernated elastic memory (CHEM) polyurethane-based foam is a novel self-deployable shape memory polymer.
  • Biocompatibility is crucial for medical applications of new materials.

Purpose of the Study:

  • To evaluate the biocompatibility and efficacy of CHEM foam for endovascular embolization.
  • To assess the potential of CHEM foam in treating aneurysms and occluding arteries.

Main Methods:

  • In vitro cytotoxicity and mutagenicity tests were performed on CHEM foam.
  • In vivo studies involved occluding canine carotid artery aneurysms and internal maxillary arteries (Imax) with CHEM foam.
  • Angiography and pathology were used to analyze outcomes at 3 and 12 weeks.

Related Experiment Videos

Main Results:

  • CHEM foam demonstrated biocompatibility in vitro.
  • CHEM foam successfully occluded Imax at 3 weeks.
  • CHEM-embolized aneurysms showed significant improvement in angiographic scores by 3 weeks, with neointima formation observed.

Conclusions:

  • CHEM foam is a biocompatible material with potential for endovascular applications.
  • The foamy structure of CHEM promotes cell ingrowth, aiding in neointima formation for aneurysm occlusion.
  • CHEM's properties may enable the development of innovative endovascular intervention devices.