Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Convulsion following intrathecal cephaloridine.

H Yoshioka, H Nambu, M Fujita

    Infection
    |January 1, 1975
    PubMed
    Summary

    Intrathecal cephaloridine administration in an infant caused seizures, confirming its neurotoxicity. Direct administration into the cerebrospinal fluid space is not recommended due to potential central nervous system damage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Enhanced Material Assimilation in a Toroidal Plasma Using Mixed H_{2}+Ne Pellet Injection and Implications to ITER.

    Physical review letters·2023
    Same author

    Electron temperature and density measurement by Thomson scattering with a high repetition rate laser of 20 kHz on LHD.

    Scientific reports·2022
    Same author

    Preceding propagation of turbulence pulses at avalanche events in a magnetically confined plasma.

    Scientific reports·2022
    Same author

    Electro-optically Q-switched operation of a high-peak-power Tb:LiYF<sub>4</sub> green laser.

    Optics express·2021
    Same author

    Efficient visible laser operation of Tb:LiYF<sub>4</sub> and LiTbF<sub>4</sub>.

    Optics express·2020
    Same author

    Graphene Q-switched Tb:LiYF<sub>4</sub> green laser.

    Optics letters·2020

    Area of Science:

    • Neonatal Neurology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Meningitis is a serious infection in infants.
    • Intrathecal drug administration is used for CNS infections.
    • Cephaloridine is an antibiotic sometimes used in treating infections.

    Observation:

    • An 11-day-old premature infant received intrathecal cephaloridine for suspected meningitis.
    • The infant experienced a generalized tonic convulsion post-administration.
    • The same convulsive symptoms recurred upon a second intrathecal cephaloridine dose.

    Findings:

    • Intrathecal cephaloridine administration directly into the cerebrospinal fluid space can induce central nervous system (CNS) toxicity.
    • The observed generalized tonic convulsion was a direct adverse effect of cephaloridine.
    • The infant's symptoms resolved over six hours, indicating a transient neurotoxic effect.

    Implications:

    • Cephaloridine should not be administered intrathecally due to its neurotoxic potential.
    • Alternative antibiotics or administration routes should be considered for CNS infections in neonates.
    • Further research into the neurotoxic mechanisms of cephaloridine is warranted.

    Related Experiment Videos