Three-dimensional structure of the inclusion complex between phloridzin and beta-cyclodextrin
Related Experiment Video
Updated: Sep 28, 2026

Construction and Systematical Symmetric Studies of a Series of Supramolecular Clusters with Binary or Ternary Ammonium Triphenylacetates
Published on: February 15, 2016
Yasuko Ishizuka1, Masako Fujiwara, Kenji Kanazawa
1Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Central-6, 1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. ishizuka.yasuko@aist.go.jp
Abstract:
The inclusion of phloridzin into beta-cyclodextrin was studied as a model of molecular recognition in membranes. Effects on 1H NMR spectra and NOE correlational peaks between phloridzin and beta-cyclodextrin were observed in the complex. Strong NOEs were observed between hydrogens of a phenol group in phloridzin and beta-cyclodextrin. The three-dimensional structure of the inclusion complex between phloridzin and beta-cyclodextrin was simulated with distance constraints estimated by the intensity of NOE peaks using the DADAS90 programs. Two inclusion possibilities were suggested-the large rim of beta-cyclodextrin as an entrance of the inclusion and the small rim of beta-cyclodextrin as the entrance. In both cases, the phenol group of phloridzin was included in the hydrophobic space of beta-cyclodextrin.
Related Concept Videos
Protein and Protein Structure
Newman Projections
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
Fischer Projections
Clathrin Coated Vesicles
Hybridization of Atomic Orbitals II
Chair Conformation of Cyclohexane
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this staggered...

