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GeneCards 2002: towards a complete, object-oriented, human gene compendium.

Marilyn Safran1, Irina Solomon, Orit Shmueli

  • 1Departments of Molecular Genetics Biological Services (Bioinformatics Unit) Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel. marilyn.safran@weizmann.ac.il

Bioinformatics (Oxford, England)
|November 9, 2002
PubMed
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GeneCards provides updated gene information and tools for functional genomics. It enhances gene analysis with new data, improved software, and methods for novel gene cards.

Area of Science:

  • Genomics
  • Bioinformatics
  • Functional Gene Analysis

Background:

  • The post-genomic era demands advanced tools for gene functional analysis.
  • Existing comprehensive resources face challenges in providing state-of-the-art capabilities.

Purpose of the Study:

  • To describe the innovative advancements and ongoing development of the GeneCards database.
  • To highlight the integration of new data types and technological improvements.

Main Methods:

  • Regularly updating and enhancing the GeneCards database with diverse gene-related information.
  • Restructuring the underlying software architecture using object-oriented programming and XML.
  • Developing pilot studies for generating gene cards for novel and predicted genes.

Related Experiment Videos

Main Results:

  • GeneCards has been regularly updated with new genes, sequences, genomic locations, and orthologies.
  • Enriched content includes medical information, protein structures, gene expression, and SNP summaries.
  • Software migration to XML and development of methods for novel gene cards were successfully implemented.

Conclusions:

  • GeneCards continues to evolve as a sophisticated resource for gene functional analysis.
  • The database provides consistently improving, state-of-the-art tools for researchers.
  • Advancements facilitate comprehensive analysis of known and novel genes.