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Related Experiment Videos

Pulmonary embolism with factor XI deficiency.

J B Brodsky, G E Burgess

    JAMA
    |December 15, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Patients with factor XI deficiency may still develop pulmonary embolism despite prolonged bleeding risks. Prophylactic programs for venous thrombosis are essential for these patients. Preoperative screening for bleeding disorders is crucial for all surgical patients.

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    Area of Science:

    • Hematology
    • Vascular Medicine
    • Thrombosis Research

    Background:

    • Factor XI deficiency is a rare inherited bleeding disorder.
    • Postoperative venous thromboembolism (VTE) is a significant clinical concern.
    • Low-dose heparin is commonly used for VTE prophylaxis.

    Observation:

    • A patient with severe factor XI deficiency (<1% of normal) experienced a pulmonary embolism.
    • The patient also had prolonged bleeding post-surgery.
    • Factor XI deficiency did not prevent the occurrence of pulmonary embolism.

    Findings:

    • Severe factor XI deficiency does not confer protection against pulmonary embolism.
    • Venous thromboembolism prophylaxis programs are necessary for factor XI-deficient patients.

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  • Preoperative partial thromboplastin time (PTT) screening can identify unsuspected bleeding disorders.

    • Implications:

    • Factor XI-deficient patients require VTE prophylaxis similar to the general surgical population.
    • Screening for bleeding disorders via PTT is vital before initiating prophylactic anticoagulation.
    • This case highlights the complex interplay between bleeding and clotting risks in factor XI deficiency.