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Thyroid function in Kuwaiti subjects with Down's syndrome.
Fawzi E Ali1, Hossam A Bayoumy, Abdul Salam R Mohammad
1Medical Rehabilitation Centre, Ministry of Social Affairs, Surra, Kuwait. fawzi@kma.org.kw
Summary
Thyroid dysfunction is prevalent in individuals with Down
Area of Science:
- Endocrinology
- Genetics
- Public Health
Background:
- Down's syndrome (DS) is associated with an increased risk of endocrine disorders.
- Thyroid dysfunction is a known complication in individuals with DS.
Purpose of the Study:
- To assess thyroid function in Kuwaiti individuals with Down's syndrome.
- To determine the prevalence of thyroid dysfunction and autoimmune thyroid disease in this population.
Main Methods:
- Thyroid function tests (TSH, T4) and antithyroid antibodies were measured.
- 58 Kuwaiti subjects with DS from residential or rehabilitation facilities were studied.
Main Results:
- 55% of subjects exhibited thyroid dysfunction, including hypothyroidism and hyperthyroidism.
- Thyroid dysfunction was newly diagnosed in 31 individuals.
- Antithyroid antibodies were present in 52% of all subjects.
Conclusions:
- Thyroid dysfunction is common in Kuwaiti individuals with DS, likely due to autoimmune thyroid disease.
- Regular thyroid function screening is recommended for individuals with DS.
- A national screening program could facilitate early detection and management.