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Thyroid function in Kuwaiti subjects with Down's syndrome.

Fawzi E Ali1, Hossam A Bayoumy, Abdul Salam R Mohammad

  • 1Medical Rehabilitation Centre, Ministry of Social Affairs, Surra, Kuwait. fawzi@kma.org.kw

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|November 9, 2002
PubMed
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Thyroid dysfunction is prevalent in individuals with Down

Area of Science:

  • Endocrinology
  • Genetics
  • Public Health

Background:

  • Down's syndrome (DS) is associated with an increased risk of endocrine disorders.
  • Thyroid dysfunction is a known complication in individuals with DS.

Purpose of the Study:

  • To assess thyroid function in Kuwaiti individuals with Down's syndrome.
  • To determine the prevalence of thyroid dysfunction and autoimmune thyroid disease in this population.

Main Methods:

  • Thyroid function tests (TSH, T4) and antithyroid antibodies were measured.
  • 58 Kuwaiti subjects with DS from residential or rehabilitation facilities were studied.

Main Results:

  • 55% of subjects exhibited thyroid dysfunction, including hypothyroidism and hyperthyroidism.

Related Experiment Videos

  • Thyroid dysfunction was newly diagnosed in 31 individuals.
  • Antithyroid antibodies were present in 52% of all subjects.

    • Conclusions:

    • Thyroid dysfunction is common in Kuwaiti individuals with DS, likely due to autoimmune thyroid disease.
    • Regular thyroid function screening is recommended for individuals with DS.
    • A national screening program could facilitate early detection and management.