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Maternal age and oral clefts: a reappraisal
Alexandre R Vieira1, Iêxeda M Orioli, Jeffrey C Murray
1Department of Pediatrics, University of Iowa, Iowa City 52242-1083, USA.
Abstract
Objective:
The aim of the study was to test the hypothesis that increased maternal age is associated with a higher risk of having a child with oral clefts.
Study Design:
A meta-analysis of 8 population-based studies with information regarding live birth and oral clefts was performed.
Results:
No association between increased maternal age and isolated oral clefts was found.
Conclusion:
Oral clefts occurrence is not correlated with increasing maternal age, and inclusion of data mixing isolated and syndromic cases can confound the analysis and must be avoided.