Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conditioned anxiety to nicotine.

Sandra E File1, Survjit Cheeta, Elaine E Irvine

  • 1Psychopharmacology Research Unit, Centre for Neuroscience, GKT School of Biomedical Sciences, King's College London, Hodgkin Building, Guy's Campus, London SE1 1UL, UK.

Psychopharmacology
|November 9, 2002
PubMed
Summary

Anxiety can be conditioned to cues associated with nicotine, but this effect is specific to the testing environment. Nicotine pre-exposure can prevent the development of conditioned anxiety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neural correlates of implicit emotion regulation in mood and anxiety disorders: an fMRI meta-analytic review.

Scientific reports·2025
Same author

Growth of the maternal intestine during reproduction.

Cell·2025
Same author

The empirical status of implicit emotion regulation in mood and anxiety disorders: A meta-analytic review.

Journal of affective disorders·2025
Same author

Growth of the maternal intestine during reproduction.

Cell·2025
Same author

Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [<sup>18</sup>F]DOPA PET in Naïve and Cocaine-Treated Mice.

Molecular imaging·2025
Same author

SETTING AN AGENDA FOR THE APPLICATION OF THE THOUGHT OF ARTHUR SCHOPENHAUER (1788-1860) IN CONTEMPORARY PSYCHIATRY, PSYCHOLOGY, AND PSYCHOTHERAPY.

Psychiatria Danubina·2024

Area of Science:

  • Neuroscience
  • Behavioral Pharmacology

Background:

  • Nicotine, despite its known reinforcing properties, can induce anxiety and anxiogenic effects in both humans and animal models.
  • Understanding the mechanisms behind nicotine-induced anxiety is crucial for addressing its complex effects.

Purpose of the Study:

  • To determine if anxiety can be conditioned to cues associated with an anxiogenic nicotine dose.
  • To assess the specificity of conditioned anxiety across different anxiety tests.
  • To investigate the influence of nicotine pre-exposure on the development of conditioned anxiogenic effects.

Main Methods:

  • Rats received an anxiogenic nicotine dose before or after social interaction (SI) testing.
  • Conditioned anxiogenic responses were assessed in drug-free re-tests 24 hours later.

Related Experiment Videos

  • Test specificity was examined by cross-testing in the elevated plus-maze and SI test.
  • The impact of short-term (4 days) and long-term (4 weeks) nicotine pre-exposure was evaluated.

    • Main Results:

    • Nicotine administration before SI testing produced an unconditioned anxiogenic effect.
    • A significant conditioned anxiogenic effect was observed only in rats previously tested with nicotine in the SI test.
    • Conditioned anxiety was specific to the SI test context, not transferable to the elevated plus-maze.
    • While 4 days of nicotine exposure did not prevent conditioned anxiety, 4 weeks of self-administration blocked its development.

    Conclusions:

    • Anxiety can be conditioned to contextual cues following exposure to an anxiogenic nicotine dose.
    • The conditioned anxiety is specific to the environment where nicotine exposure occurred.
    • Nicotine pre-exposure, particularly long-term, can inhibit the development of conditioned anxiogenic responses.