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[Vanishing bile duct syndrome following allogeneic bone marrow transplantation]
1Klinik für Kinder- und Jugendmedizin, Universitätskliniken des Saarlandes, Homburg, Germany.
Background:
Cholestasis following bone marrow transplantation is not rare, but should always be a warning signal. The main causes of cholestasis following bone marrow transplantation are hepatotoxic effects of drugs, venoocclusive disease (VOD), early graft-versus-host disease (GvHD), total parenteral nutrition, viral hepatitis, sepsis and opportunistic infections. Vanishing bile duct syndrome represents a very rare cause for cholestatic symptoms.
Case Report:
We report on a 8-year-old boy suffering from myelodysplastic syndrome, who underwent allogeneic bone marrow transplantation and developed biliary ductopenia in terms of a vanishing bile duct syndrome.
Conclusion:
Differential diagnosis for cholestasis following bone marrow transplantation should include the vanishing bile duct syndrome.