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Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease

Steven Jacobson1

  • 1Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke/NIH, Bldg. 10, Rm. 5B-16, 9000 Rockville Pike, Bethesda, MD 20892, USA. jacobsons@ninds.nih.gov

The Journal of Infectious Diseases
|November 9, 2002
PubMed

This review focuses on current approaches to understanding the immunopathogenesis of human T cell lymphotropic virus (HTLV) type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) based on newly developed molecular and immunologic techniques that have been adapted to studies of HTLV-I proviral load, HTLV-I mRNA, and HTLV-I tax-specific CD8 T cells. These methods enable researchers to study previously inaccessible aspects of this disease and allow a more detailed analysis of virus/host immune responses as they relate to disease specificity in this disorder. The role of HTLV-I-specific CD8 T cell immune responses is highlighted. The elucidation of the immunopathology of HAM/TSP will enhance our understanding of other HTLV-I-associated disorders plus other neurologic, hematologic, and inflammatory diseases for which viral etiologies have been suggested.

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