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Adjuvant therapy for resected gastric carcinoma
Yuichi Kasakura1, Alexandria Phan, Jaffer Ajani
1Department of Gastrointestinal Oncology, University of Texas M.D. Anderson Cancer Center, 1400 Holcombe Boulevard, Box 426, Houston, TX 77030-4009, USA.
Surgical Oncology Clinics of North America
|November 12, 2002
Summary
Gastric carcinoma remains a global health issue, particularly in Asia, despite declining rates. Effective adjuvant therapies are crucial due to high relapse risks after surgery.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Gastric carcinoma, though declining, is a significant global health concern, especially in Asian countries.
- Incidence varies geographically, with rising proximal gastric carcinoma rates in North America.
- Gastric cancer is a leading cause of cancer death in many regions and ranks 10th in US mortality.
Purpose of the Study:
- To highlight the global burden of gastric carcinoma.
- To underscore the need for improved detection and treatment strategies.
- To emphasize the necessity of effective adjuvant therapies post-resection.
Main Methods:
- Review of epidemiological data on gastric carcinoma incidence and mortality.
- Analysis of geographical variations in gastric cancer prevalence.
- Examination of current screening practices and treatment outcomes.
Main Results:
- Gastric carcinoma incidence has declined over 40 years but remains a major cause of cancer death globally.
- Significant regional disparities exist, with high mortality rates in Asia and rising proximal rates in North America.
- Japan employs mass screening, a practice not widespread elsewhere.
Conclusions:
- Despite declining trends, gastric carcinoma poses a substantial global health challenge.
- Effective adjuvant therapy is urgently needed for patients with gastric carcinoma post-curative resection.
- Further research into early detection and novel therapeutic strategies is warranted.