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Updated: Sep 28, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
[Recanalization of chronic coronary occlusions]
1II. Interne Abteilung mit Kardiologie und Internistischer Intensivmedizin, A. ö. Krankenhaus der Barmherzigen Schwestern vom Heiligen Kreuz, Grieskirchnerstrasse 42, A-4600 Wels. johann.auer@khwels.at
Insights
Percutaneous coronary interventions can successfully recanalize chronic coronary occlusions, improving patient outcomes. While one guidewire often suffices, additional wires enhance success rates in challenging cases.
Area of Science:
- Cardiology
- Interventional Cardiology
Context:
- Chronic coronary occlusion is a frequent finding in diagnostic angiography.
- It often influences the decision for surgical revascularization over percutaneous coronary interventions (PCI).
- Successful recanalization can alleviate angina and improve left ventricular function.
Purpose:
- To correlate primary success rates of attempted coronary recanalizations with lesion localization and procedural characteristics.
- To characterize lesions amenable to successful recanalization.
Summary:
- A study analyzed 124 patients undergoing attempted recanalization of chronic coronary occlusions.
- Overall success rate was 67.7%, with no significant difference between the left anterior descending artery and other vessels.
- Successful recanalization was often achieved with a single guidewire, though additional wires improved success in initially failed procedures.
Impact:
- The findings suggest that recanalization of chronic occluded coronary arteries is feasible with a high success rate in unselected patients.
- Procedural techniques, including the judicious use of multiple guidewires, can optimize outcomes.
- Coronary stenting is frequently employed following successful recanalization, particularly in the left anterior descending artery.
Abstract:
Recanalization of occluded coronary arteries is the aim of percutaneous interventions with acute myocardial infarction. Moreover, chronic coronary occlusion is a common finding during diagnostic coronary angiography and is often a contributing factor in the choice of revascularisation by surgery rather than by percutaneous coronary interventions (PCI). An occluded coronary artery with some degree of collateral supply is functionally comparable to a severe coronary stenosis. Therefore, recanalization of chronic occluded coronary arteries results in less angina and often in improvement of left ventricular function. Success is limited in particular in longer lasting occlusions. Characterization of lesions, where recanalization can performed successfully is warranted. We correlated primary success rates of attempted coronary recanalizations with localisation of lesions and procedural characteristics. We analyzed records of 124 consecutive patients, who underwent attempted coronary recanalization of chronically occluded coronary arteries at our institution in 1998. Revascularisation was successful in 84 (64 male, 20 female) of 124 (92 male, 32 female) patients. Therefore, success rate was 67.7% (69.9% in men, 62.5% in women, p = 0.42). Target vessel was the left anterior descending artery (LAD) in 49 cases. Success rate in the LAD did not differ significantly from that in "non-LAD"-vessels (65.3% versus 69.3%; p = 0.35). Successful recanalizations were performed using only one guide-wire in 77.3%. More than one guide-wires were used during procedures without success in 44.5% and exceeded use in successful interventions (p < 0.05). Procedures, failing to be successful after an attempt with a first guide-wire, could be performed successfully using at least a second wire in 50%. Coronary stenting after recanalization has been performed in 84.4% in the LAD and in 59.7% in non-LAD vessels (p < 0.01). Success rate of attempted recanalizations of chronic occluded coronary arteries in unselected patients is high. Most procedures can be performed successfully using only one guidewire. Additional use of other wires can increase success rates in procedures with primary failure to pass the occlusion. Stenting has been performed in three out of four patients with successful recanalization of chronically occluded coronary arteries.
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