Related Experiment Videos
[Cerebral ischemia and histamine].
1Department of Anesthesiology and Resuscitology, Ehime University School of Medicine, Ehime 791-0295, Japan. nadachi@m.ehime-u.ac.jp
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|November 12, 2002
Summary
Central histamine protects against ischemic neuronal damage by reducing excitatory neurotransmitter release. However, histamine H2 receptor activation can worsen cerebral edema by increasing blood-brain barrier permeability.
Area of Science:
- Neuroscience
- Neurochemistry
- Cerebrovascular Research
Context:
- Cerebral ischemia triggers excessive glutamate release and intracellular calcium increase, leading to neuronal injury.
- Histamine functions as a neurotransmitter in the central nervous system, with widespread histaminergic projections.
- Histamine release and activity are altered during cerebral ischemia, impacting neuronal survival.
Purpose:
- To investigate the role of central histamine in mitigating neuronal damage during cerebral ischemia.
- To elucidate the specific effects of histamine H2 receptor activation on ischemic injury and neurotransmitter release.
Summary:
- Inhibition of histaminergic activity exacerbates ischemic damage, while histamine administration shows protective effects.
- Blockade of histamine H2 receptors worsens ischemic injury and increases the release of glutamate and dopamine.
- Central histamine appears to protect against ischemic neuronal damage by suppressing excitatory neurotransmitter release.
Impact:
- Histamine H2 receptor activation may offer neuroprotection against ischemic stroke by modulating neurotransmitter systems.
- Understanding histamine's dual role is crucial, as H2 receptor activation also increases blood-brain barrier permeability and cerebral edema.