[Roles of integrins and cytoskeleton in cellular mechanotransduction]

Integrins and cytoskeleton play important role in the conversion of mechanical signals into intracellular biochemical signals followed by physiological or pathological responses. At the same time, the system of extracellular matrix (ECM)-integrins-cytoskeleton (CSK) axis is in close connection with ion channels and signal transduction, and they interact with each other.