Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Formulations and nebulizer performance.

Thomas G O'Riordan1

  • 1Pulmonary/Critical Care Division, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8172, USA. toriordan@mail.som.sunysb.edu

Respiratory Care
|November 12, 2002
PubMed
Summary

Nebulizer drug delivery involves dispersing medications in liquid for inhalation. Formulations impact efficiency, with solutions generally performing better than suspensions, especially in ultrasonic nebulizers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-acting β<sub>2</sub> agonist (LABA) with a long-acting muscarinic receptor antagonist (LAMA) promotes human airway smooth muscle (HASM) relaxation and circumvents β<sub>2</sub> adrenergic receptor tachyphylaxis.

Respiratory research·2025
Same author

Leveraging Machine Learning and Real-World Data to Predict Chronic Obstructive Pulmonary Disease Exacerbations.

International journal of chronic obstructive pulmonary disease·2025
Same author

Optimizing Aerosolized Drug Delivery in Clinical Trials in Patients Undergoing Mechanical Ventilation.

Journal of aerosol medicine and pulmonary drug delivery·2024
Same author

Risk factors for disease progression in idiopathic pulmonary fibrosis.

Thorax·2019
Same author

Quantitative high-resolution computed tomography fibrosis score: performance characteristics in idiopathic pulmonary fibrosis.

The European respiratory journal·2018
Same author

Using hyperpolarized <sup>129</sup>Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis.

Thorax·2017

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Aerosol Science

Background:

  • Nebulization requires dispersing drugs in liquid media for aerosol droplet inhalation.
  • Drug solubility varies, necessitating cosolvents or suspensions, impacting nebulizer efficiency.
  • Formulations include active ingredients, solvents, buffers, stabilizers, and preservatives, influencing drug delivery.

Purpose of the Study:

  • To review drug formulation strategies for nebulization.
  • To discuss factors affecting nebulizer performance and drug delivery efficiency.
  • To highlight advancements in delivering challenging drug compounds via nebulization.

Main Methods:

  • Literature review of drug formulation and nebulizer technology.
  • Analysis of factors influencing aerosol generation and particle size.
  • Comparison of nebulizer types (jet vs. ultrasonic) and their efficiency with different formulations.

Main Results:

  • Solutions are generally more efficiently nebulized than suspensions, particularly with ultrasonic devices.
  • Novel strategies like liposomes and nanoparticles improve delivery of non-water-soluble drugs.
  • Formulation components and nebulizer choice significantly affect inhaled mass, particle size, and treatment duration.

Conclusions:

  • Optimizing drug formulation and nebulizer selection is crucial for effective inhaled therapy.
  • Emerging technologies enhance the delivery of poorly soluble drugs and complex molecules.
  • Trends favor single-use, preservative-free formulations to minimize adverse events and ensure drug integrity.

Related Experiment Videos