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Updated: Sep 28, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
Published on: March 14, 2025
Association of obsessions and compulsions in schizophrenia with neurocognition and negative symptoms
Paul H Lysaker1, Gary J Bryson, Kriscinda A Marks
1Day Hospital 116H, Roudebush VA Medical Center, 1481 West 10th Street, Indianapolis, IN 46202, USA. Lysaker.Paul_H_PHD@Indianapolis.va.gov
Abstract:
It is unclear whether obsessions and compulsions in schizophrenia spectrum disorders are associated with a unique pattern of symptoms and deficits. Accordingly, the present study compared symptom levels and neurocognitive function of participants with schizophrenia or schizoaffective disorder with (n=11) and without (n=52) significant obsessive-compulsive symptoms. Analyses of variance revealed that the obsessive-compulsive group performed more poorly on measures of executive function and vigilance and had higher levels of negative and emotional discomfort symptoms. Unexpectedly, the obsessive-compulsive group also demonstrated superior performance on a measure of visual memory. The implications of these clinical correlates of obsessive-compulsive phenomena in schizophrenia spectrum disorders are discussed.
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