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Updated: Sep 8, 2026
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
Published on: November 8, 2011
B-Cell lymphoproliferative disorder not associated with Epstein-Barr Virus in a child with relapsed acute
Thomas Lehrnbecher1, Andreas Trusen, Frank Deinlein
1Department of Pediatrics, University of Würzburg, Germany. thomas_lehrnbecher@yahoo.com
Abstract:
Lymphoproliferative disorder (LPD) is described in only a few children receiving chemotherapy for cancer. In all of them, an association between LPD and EBV (Epstein-Barr Virus) was found. We report on a patient who developed LPD not associated with EBV while receiving chemotherapy for relapsed acute lymphoblastic leukemia (ALL). Despite discontinuation of chemotherapy, administration of intravenous immunoglobulins and surgery the patient died. Growing experience with this disorder may allow better treatment options in the future and will show whether LPD not associated with EBV requires different therapeutic strategies.
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