Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Charge-oriented modelling in charge-transfer systems.

M U Adikwu1, H D Höltje

  • 1Department of Pharmaceutics Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.

Bollettino Chimico Farmaceutico
|November 13, 2002
PubMed
Summary

This study models charge-transfer interactions between electron donors and acceptors. A novel charge-oriented mechanism is proposed for solvent systems where traditional Lewis acid-base interactions are unfavorable.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure-based virtual screening and molecular dynamics simulation studies to discover new SARS-CoV-2 main protease inhibitors.

Scientific African·2021
Same author

SRMS142-based solid lipid microparticles: application in oral delivery of glibenclamide to diabetic rats.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2010
Same author

Preparation and evaluation of mucin-gelatin mucoadhesive microspheres for rectal delivery of ceftriaxone sodium.

Drug development and industrial pharmacy·2007
Same author

Evaluation of mucin as a release enhancer for rectal delivery of glibenclamide.

Current drug delivery·2006
Same author

Development of models for cytochrome P450 2A5 as well as two of its mutants.

Die Pharmazie·2005
Same author

Melt extrusion bioadhesive delivery of diclofenac sodium granules using theobroma oil.

Bollettino chimico farmaceutico·2004

Area of Science:

  • Chemistry
  • Physical Chemistry
  • Computational Chemistry

Background:

  • Charge-transfer interactions are fundamental in chemical reactions.
  • The Lewis acid-base mechanism is commonly accepted for electron donor-acceptor interactions.
  • Understanding these interactions is crucial for various chemical processes.

Purpose of the Study:

  • To investigate and model charge-transfer interactions between electron donors and acceptors.
  • To examine the commonly accepted Lewis acid-base interaction mechanism.
  • To propose and explore an alternative charge-oriented mechanism.

Main Methods:

  • A computational modeling approach was employed.
  • Simulations were performed to analyze interaction mechanisms.
  • Analysis focused on charge distribution and interaction energies.

Main Results:

  • The study validated the Lewis acid-base interaction model in certain systems.
  • A charge-oriented mechanism was identified as significant.
  • This alternative mechanism is particularly relevant in specific solvent environments.

Conclusions:

  • The Lewis acid-base model is not universally applicable for all charge-transfer interactions.
  • A charge-oriented mechanism provides a valuable alternative explanation.
  • This finding expands the understanding of electron donor-acceptor interactions in diverse solvent systems.

Related Experiment Videos