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Spectrophotometric determination of sulphacetamide
R Girdhar1, V K Jain, S K Menon
1Pharmacy Department, Faculty of Technology, M.S. University of Baroda, India.
Bollettino Chimico Farmaceutico
|November 13, 2002
Abstract:
A new rapid selective spectrophotometric method for the determination of sulphacetamide is described. The drug forms a orange-yellow colored complex with Cerium(IV) in sulfuric acid media which is extracted into ethyl acetate. The complex exhibits a maximum absorbance at 440 nm with a molar absorptivity of 3 x 10(2) 1 mol-1 cm-1. The system obeys Beer's law in the concentration range of 0.07-1.1 mg of sulphacetamide. The various parameters for the optimum extraction conditions are discussed. The method is applied to the determination of sulphacetamide in dosage forms.