Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cytometric analyses in systemic autoimmune diseases].

T Dörner1, M Odendahl, A Radbruch

  • 1Med. Klinik m. S. Rheumatologie und Klin. Immunologie, Charité Berlin Schumannstr. 20/21 10098 Berlin, Germany. thomas.doerner@charite.de

Zeitschrift Fur Rheumatologie
|November 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Practical management of Sjögren's disease in the era of new treatment options : Current value of available outcome parameters].

Zeitschrift fur Rheumatologie·2026
Same author

[Management of systemic lupus erythematosus-Including secondary antiphospholipid syndrome, fertility and pregnancy : S3 guidelines of the German Society for Rheumatology and Clinical Immunology and the German Society for Neurology (DGN), German Society for Internal Medicine (DGIM), German Cardiac Society (DGK), Society for Thrombosis and Hemostasis Research (GTH), German Society for Hematology and Medical Oncology (DGHO), German Society for Pediatric and Adolescent Medicine (DGKJ), Society for Pediatric and Adolescent Rheumatology (GKJR), German Society for Nephrology (DGfN), German Society for Pneumology and Ventilation Medicine (DGP), German Rheumatism League National Association, Lupus Erythematosus Self-help Community, German Dermatological Society (DDG). Version: 1.2].

Zeitschrift fur Rheumatologie·2025
Same author

[Influence of underlying disease and immunosuppression on the immunocompetence in inflammatory rheumatic diseases].

Zeitschrift fur Rheumatologie·2023
Same author

Automated Detection of Cerebral Aneurysms on TOF-MRA Using a Deep Learning Approach: An External Validation Study.

AJNR. American journal of neuroradiology·2022
Same author

Induction of cross-reactive, mucosal anti-SARS-CoV-2 antibody responses in rheumatoid arthritis patients after 3rd dose of COVID-19 vaccination.

Journal of autoimmunity·2022
Same author

[80 milestones in rheumatology from 80 years-IV. 2000-2020].

Zeitschrift fur Rheumatologie·2021
Same journal

[Prevention strategies in rheumatoid arthritis : From primary prevention to targeted drug interception].

Zeitschrift fur Rheumatologie·2026
Same journal

Methodological concerns and data discrepancies in the indirect treatment comparison of belimumab and anifrolumab.

Zeitschrift fur Rheumatologie·2026
Same journal

Evaluating the comparative efficacy of belimumab vs. anifrolumab in systemic lupus erythematosus: a response.

Zeitschrift fur Rheumatologie·2026
Same journal

[Update: DMARDs for MGUS].

Zeitschrift fur Rheumatologie·2026
Same journal

[A potpourri of diagnoses-Unusual manifestations of a chronic inflammatory bowel disease : Case report].

Zeitschrift fur Rheumatologie·2026
Same journal

[Not measurable but immeasurably important : Fever-The leading symptom of ancient medical theory].

Zeitschrift fur Rheumatologie·2026
See all related articles

Autoantibodies are key in collagen vascular diseases. Disturbances in B cell homeostasis, particularly in systemic lupus erythematosus (SLE) and Sjögren's syndrome, offer new diagnostic and therapeutic insights.

Area of Science:

  • Immunology
  • Rheumatology
  • Cell Biology

Context:

  • Collagen vascular diseases are often diagnosed using autoantibody markers.
  • Limited data exists on precursor cell disturbances leading to autoantibody-producing plasma cells.
  • B cell homeostasis is increasingly recognized as a factor in autoimmune diseases.

Purpose:

  • To investigate disturbances in B cell homeostasis in systemic lupus erythematosus (SLE) and Sjögren's syndrome.
  • To explore the immunopathogenesis of these autoimmune conditions.
  • To identify potential new diagnostic and therapeutic strategies.

Summary:

  • Autoantibodies are significant in diagnosing and understanding collagen vascular diseases.
  • Peripheral B cell compartments in SLE and Sjögren's syndrome show characteristic differences from normal.

Related Experiment Videos

  • While identifying autoreactive B cells is ongoing, B cell subset differences enhance understanding of disease mechanisms.

    • Impact:

    • Provides insights into the immunopathogenesis of SLE and Sjögren's syndrome.
    • Highlights the role of B cell homeostasis in autoimmune diseases.
    • Suggests potential for novel diagnostic markers and therapeutic targets.