Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Frontostriatal and limbic dysfunction in late-life depression.

George S Alexopoulos1

  • 1Weill Medical College of Cornell University, White Plains, NY 10605, USA. gsalexop@med.cornell.edu

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|November 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Dialectic View of Late-life.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
Same author

Effect of continuation treatment on health-related quality of life in remitted psychotic depression.

Journal of affective disorders·2026
Same author

Beyond the biological decline of aging: The evolution of critical phenomenology.

International psychogeriatrics·2026
Same author

Beyond the biological decline of aging: From phenomenology to 4E cognitive science.

International psychogeriatrics·2026
Same author

Clozapine in Older Adults: Benefits and Challenges.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026
Same author

Decline of Aging: Aesthetics and Ethics of Care.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2026

Frontostriatal and limbic dysfunction are implicated in geriatric depression, potentially contributing to its development and poor outcomes. Further research using advanced imaging can clarify these brain network roles.

Area of Science:

  • Neuroscience
  • Geriatric Psychiatry
  • Cognitive Science

Background:

  • Late-life depression is frequently associated with frontostriatal and limbic system dysfunction.
  • These brain changes may stem from aging or play a direct role in geriatric depression's pathophysiology.
  • Frontostriatal dysfunction is observed in younger depressed individuals and linked to adverse outcomes in older adults.

Purpose of the Study:

  • To investigate the pathogenetic role of frontostriatal and limbic dysfunction in late-life depression.
  • To explore the relationship between brain dysfunction and the course of geriatric depression.
  • To leverage cognitive-neuroscience and brain-imaging to understand networks involved in late-life depression.

Main Methods:

  • Review of studies documenting frontostriatal and limbic dysfunction in late-life depression.

Related Experiment Videos

  • Analysis of the association between frontostriatal dysfunction and depression outcomes.
  • Proposed integration of cognitive-neuroscience and brain-imaging techniques with clinical course studies.

    • Main Results:

    • Frontostriatal and limbic dysfunction are consistently observed in late-life depression.
    • This dysfunction is potentially linked to poorer short- and long-term outcomes.
    • The precise pathophysiological role requires further investigation due to methodological limitations.

    Conclusions:

    • Frontostriatal and limbic dysfunction are relevant to geriatric depression's development and course.
    • Despite limitations like selective survival and confounding clinical factors, combined approaches are valuable.
    • Advanced neuroimaging and cognitive studies are crucial for elucidating the neural networks underlying late-life depression.