Related Experiment Video
Updated: Jul 12, 2026
10:34
An In-vitro Preparation of Isolated Enteric Neurons and Glia from the Myenteric Plexus of the Adult Mouse
Published on: August 7, 2013
Role of nerves in enteric infection
1Division of Gastroenterology, University Hospital, Nottingham, UK. robin.spiller@nottingham.ac.uk
Gut
|November 13, 2002
Summary
Nerves are crucial for fighting enteric infections by controlling gut responses. Modulating these neural pathways offers new therapeutic targets for acute and chronic gut disorders.
Area of Science:
- Neurogastroenterology
- Infectious Diseases
- Pharmacology
Background:
- Enteric infections trigger immediate neural responses in the gut.
- Nerves orchestrate pathogen expulsion via intestinal secretion and motor patterns.
- Understanding neural involvement is key to managing infection outcomes.
Purpose of the Study:
- To explore the peripheral and central effects of enteric infection on the nervous system.
- To highlight the role of nerves in the host's immediate response to enteric pathogens.
- To identify potential therapeutic targets within the neural response to infection.
Main Methods:
- Review of laboratory studies on neural modulation in enteric infection.
- Analysis of the mechanisms by which nerves control intestinal secretion and motility.
- Examination of therapeutic strategies targeting neural pathways.
Main Results:
- Nerves are vital for immediate pathogen expulsion during enteric infection.
- Modulating the neural response with therapeutic agents significantly impacts infection outcomes.
- Emerging understanding reveals new therapeutic avenues for infection-induced disorders.
Conclusions:
- The nervous system plays a critical role in the host defense against enteric infections.
- Targeting neural pathways presents promising therapeutic strategies for acute and chronic enteric infections.
- Further research into neuro-immune interactions will uncover novel interventions for gastrointestinal disorders.
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