Mania following deep brain stimulation for Parkinson's disease
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Updated: Sep 28, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
J Kulisevsky1, M L Berthier, A Gironell
1Movement Disorders Unit, Department of Neurology, Functional Neurosurgery Program for Movement Disorders, Sant Pau Hospital, Autonomous University of Barcelona, Spain. jkulisevsky@hsp.santpau.es
Abstract:
Three patients with PD developed manic behavior after bilateral implantation of electrodes for deep-brain stimulation (DBS). Common to all three patients were manic symptoms unremitting after levodopa reduction or stimulation "off," lower electrodes positioning caudal to the subthalamic nucleus area, postoperative DBS with the lower contacts (0) of the quadripolar electrodes, and resolution of the manic episodes coinciding with stimulation through higher contacts.
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