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Updated: Aug 6, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
CNS demyelination associated with copper deficiency and hyperzincemia
C I Prodan1, N R Holland, P J Wisdom
1Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. calin-prodan@ouhsc.edu
Abstract:
CNS demyelination is not a previously reported feature of acquired copper deficiency. The authors report two patients with idiopathic hypocupremia and hyperzincemia, hematologic changes of copper deficiency, and extensive CNS demyelination. Hematologic recovery followed copper supplementation, both initially and after relapse off copper therapy, while serum zinc levels remained high and the neurologic abnormalities only stabilized.
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