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Boron supplementation and activated factor VII in healthy men
J M W Wallace1, M P A Hannon-Fletcher, P J Robson
1Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, Northern Ireland, UK. j.wallace@ulster.ac.uk
European Journal of Clinical Nutrition
|November 13, 2002
Summary
Acute boron supplementation did not affect postprandial levels of coagulation factor VIIa in healthy men. This study investigated boron
Area of Science:
- Biochemistry
- Nutrition Science
- Hematology
Background:
- Coagulation factor VIIa (VIIa) plays a crucial role in hemostasis.
- Boron is an essential trace element with potential roles in metabolic processes.
- The impact of acute boron supplementation on coagulation factors requires further investigation.
Purpose of the Study:
- To determine if acute boron supplementation influences postprandial concentrations of activated coagulation factor VII (VIIa).
- To assess the effect of boron on other metabolic markers, including insulin, glucose, and lipids.
Main Methods:
- A randomized, double-blind, placebo-controlled, cross-over study involving 15 healthy men aged 45-65.
- Subjects received either 11.6 mg of boron or a placebo with a high-fat meal.
- Blood samples were collected over 6 hours post-meal and analyzed for boron, insulin, glucose, lipids, and coagulation factors (VIIa, VII antigen, IX, X).
Main Results:
- Plasma boron levels were significantly elevated after boron supplementation.
- No significant changes were observed in insulin, glucose, or lipid concentrations.
- Factor VIIa levels increased significantly after the high-fat meal, but this increase was not affected by boron supplementation.
Conclusions:
- Acute boron supplementation at 11.6 mg does not alter postprandial factor VIIa activity after a high-fat meal.
- Further research may be needed to explore long-term effects or different dosages of boron on coagulation.