Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokines that regulate autoimmune myocarditis.

Michael O Kurrer1, Manfred Kopf, Josef M Penninger

  • 1Department of Pathology, University Hospital, Zurich, Switzerland.

Swiss Medical Weekly
|November 13, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNA-LNP-mediated in vivo prime editing corrects disease phenotypes in a mouse model of citrullinemia type I.

Science translational medicine·2026
Same author

IL-33-induced ILC2 effector cytokine responses promote the expansion of red pulp macrophages.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The phospholipid profile of T cells shapes ACSL4 dependency and ferroptosis sensitivity of naive, effector, and memory T cells.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Type I IFN-dependent FcγRIV signaling in murine monocytes promotes lethal anaphylaxis during viral infections.

The Journal of clinical investigation·2026
Same author

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma.

Cancer cell·2025
Same author

Versatile and Scalable Nanoparticle Vaccine as a Scaffold Against Newly Emerging Influenza Viruses.

Viruses·2025
Same journal

Metamizole-induced agranulocytosis: utilisation trends, pharmacovigilance signals and regulatory risk-minimisation in Switzerland.

Swiss medical weekly·2026
Same journal

Female genital mutilation/cutting and risk of obstetric anal sphincter injury at delivery.

Swiss medical weekly·2026
Same journal

Drug prescription before and after implementation of a CPOE system on the Paediatric Intensive Care Unit: a quality improvement study.

Swiss medical weekly·2026
Same journal

Trends in health- and lifestyle-related aspects in women of childbearing age: analysis of Swiss Health Survey data between 1992 and 2022.

Swiss medical weekly·2026
Same journal

Microplastics in the air and potential health risks - a narrative review.

Swiss medical weekly·2026
Same journal

Potentially inappropriate medication: prevalence, risk of hospitalisation and associated healthcare costs in the general older population of Switzerland.

Swiss medical weekly·2026
See all related articles

Autoimmune responses drive myocarditis and cardiomyopathy. Understanding cytokine and chemokine roles in cardiac inflammation is key for future therapies and vaccine design.

Area of Science:

  • Immunology
  • Cardiology
  • Pathogenesis of cardiac inflammation

Background:

  • Autoimmune responses are increasingly implicated in myocarditis and postinfectious cardiomyopathy.
  • Cardiac autoimmunity can be triggered by ischemic or traumatic heart damage.
  • Rodent models using cardiac alpha myosin peptides mimic myocarditis leading to heart failure.

Purpose of the Study:

  • To investigate the role of cytokines and chemokines in the pathogenesis of myocarditis.
  • To elucidate the mechanisms of immune regulation in cardiac inflammation.
  • To identify key regulatory molecules for potential therapeutic strategies.

Main Methods:

  • Utilized gene targeting to study immune regulatory molecules.
  • Employed antibodies and antagonists to block cytokines and their receptors.

Related Experiment Videos

  • Analyzed the roles of T-cells and antigen-presenting cells in immune responses.

    • Main Results:

    • Cytokines and chemokines, produced by T-cells and antigen-presenting cells, modulate immune responses.
    • Specific regulatory molecules were found to be involved in myocarditis pathogenesis.
    • Pro- and anti-inflammatory pathways associated with cardiac inflammation were identified.

    Conclusions:

    • Identification of key cytokines and pathways offers insights into myocarditis.
    • Findings have significant implications for developing future therapeutic strategies for heart conditions.
    • Understanding these mechanisms is crucial for future vaccine design to prevent autoimmune myocarditis.