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[Relation between physical activity, muscle function and IGF-1, testosterone and DHEAS concentrations in the
M Bonnefoy1, M C Patricot, J R Lacour
1Service de médecine gériatrique, centre hospitalier Lyon-Sud, 69495 Pierre-Bénite, France. marc.bonnefoy@chu-lyon.fr
La Revue De Medecine Interne
|November 14, 2002
Summary
Physical activity and cardiorespiratory fitness are linked to higher levels of dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) in elderly women. Exercise may positively influence anabolic hormone production in older adults.
Area of Science:
- Gerontology
- Endocrinology
- Exercise Physiology
Context:
- Age-related decline in muscle mass and function is associated with lower anabolic hormones.
- Hormone replacement therapies have limitations, necessitating alternative strategies.
- Exercise may influence age-related hormonal changes.
Purpose:
- To investigate the relationship between physical activity, quadriceps muscle function, and anabolic hormones (DHEAS, IGF-1, testosterone) in healthy elderly individuals.
- To confirm previous findings using methods suitable for the elderly population.
- To examine cardiorespiratory fitness (VO2max) alongside muscle function and hormone levels.
Summary:
- In elderly women, physical activity (mean habitual daily energy expenditure and sports activity) correlated significantly with IGF-1 and DHEAS levels.
- Quadriceps muscle power (Pmax) and cardiorespiratory fitness (VO2max) were also associated with DHEAS and IGF-1 in women.
- No significant correlations were observed between these variables in elderly men.
Impact:
- Findings suggest a positive influence of exercise on anabolic hormone production in elderly women.
- Physical activity, muscle function, and cardiorespiratory fitness are linked to circulating DHEAS and IGF-1.
- Highlights the potential of exercise as a strategy to mitigate age-related hormonal decline.