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Related Experiment Videos

Neuropsychological functioning in chronic Lyme disease.

Holly James Westervelt1, Robert J McCaffrey

  • 1Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA.

Neuropsychology Review
|November 14, 2002
PubMed
Summary

Chronic Lyme disease can cause cognitive issues, particularly affecting frontal brain systems. Research indicates these neuropsychological deficits are consistent with brain imaging findings.

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Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Psychology

Background:

  • Lyme disease is a prevalent vector-borne illness in the U.S.
  • Chronic Lyme disease may lead to multisystemic issues, including neuropsychological deficits.
  • Limited empirical research exists on the neuropsychological sequelae of chronic Lyme disease.

Purpose of the Study:

  • To review and synthesize existing literature on neuropsychological deficits in chronic Lyme disease.
  • To explore the relationship between these deficits and frontal systems involvement.
  • To discuss clinical presentations and central issues impacting cognitive function.

Main Methods:

  • Literature review of empirical studies on chronic Lyme disease and neuropsychological sequelae.
  • Analysis of observed cognitive deficits in relation to brain system involvement.
  • Synthesis of findings with neuroradiologic and clinical observations.

Main Results:

  • Neuropsychological deficits in chronic Lyme disease often align with frontal systems involvement.
  • Observed deficits are consistent with neuroradiologic findings.
  • The study discusses the impact of chronic illness, treatment response, and associated symptoms like depression and fatigue.

Conclusions:

  • Neuropsychological deficits are a significant concern in chronic Lyme disease.
  • Frontal systems involvement appears key in understanding these cognitive impairments.
  • Further research is needed to fully elucidate the complex factors influencing cognitive function in chronic Lyme disease.

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