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The trypanosomal trans-sialidase: two catalytic functions associated with one catalytic site
Peter M Colman1, Brian J Smith
1Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia.
Structure (London, England : 1993)
|November 14, 2002
Abstract:
The structure of the trypanosomal trans-sialidase reveals a canonical sialidase catalytic site elaborated with a conformational switch that creates an adjacent binding pocket for lactose.