Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medial temporal lobe activity during semantic classification using a flexible fMRI design.

Sander M Daselaar1, Dick J Veltman, Serge A R B Rombouts

  • 1Institute for Research in Extramural Medicine, Vrije Universiteit Medical Center, c/o Secr EMGO Dept vd Boechorstraat 7, 1081 BT Amsterdam, The Netherlands. sm.daselaar@vumc.nl

Behavioural Brain Research
|November 14, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.

Molecular psychiatry·2026
Same author

Regional, functional and transcriptomic decoding of multidimensional brain structure alterations in obsessive-compulsive disorder.

Nature communications·2026
Same author

Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.

Translational psychiatry·2026
Same author

Altered neurodevelopmental trajectories of brain structure in Tourette syndrome and Chronic Tic Disorders.

medRxiv : the preprint server for health sciences·2026
Same author

Brain age prediction in generalized anxiety disorder using a convolutional neural network.

Translational psychiatry·2026
Same author

The cost-effectiveness of predictive algorithm guided primary antidepressant treatment: economic evaluation of the multinational PReDicT randomised controlled trial.

BJPsych open·2026

This study validated a self-paced functional MRI (fMRI) design for semantic memory tasks. Findings suggest the medial temporal lobe (MTL) is involved in semantic retrieval, similar to episodic memory.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neuroimaging

Background:

  • Functional MRI (fMRI) is a key tool for studying brain activity.
  • Task switching can influence fMRI results, necessitating careful design.
  • The role of the medial temporal lobe (MTL) in semantic memory is debated.

Purpose of the Study:

  • To evaluate a self-paced fMRI design for flexible response speeds.
  • To minimize task-switching effects in fMRI studies.
  • To test the hypothesis of medial temporal lobe (MTL) involvement in semantic memory.

Main Methods:

  • A self-paced fMRI design with four alternating stimulus blocks was employed.
  • Young subjects performed a semantic retrieval task (living/nonliving classification).

Related Experiment Videos

  • Activity patterns were compared to a perceptual classification task.

    • Main Results:

    • The fMRI design demonstrated applicability, showing activity in expected lateral temporal and inferior frontal regions.
    • Significant activity was observed in the right MTL.
    • Activity was also detected in the left MTL at a lower threshold.

    Conclusions:

    • The self-paced fMRI design is suitable for studying semantic memory.
    • Results support the involvement of the MTL in semantic memory retrieval.
    • This design is intended for future studies with elderly and demented populations.