Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Toward maintaining the genome: DNA damage and replication checkpoints.

Kara A Nyberg1, Rhett J Michelson, Charles W Putnam

  • 1Molecular and Cellular Biology Department, University of Arizona, Tucson, Arizona, 85721, USA. knyberg@email.arizona.edu

Annual Review of Genetics
|November 14, 2002
PubMed
Summary

DNA checkpoints maintain genome stability and are crucial in cancer. This review details how DNA damage triggers these checkpoints, their protein interactions, and links to cancer development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The nude rat is capable of mounting a strong fibrotic response against cell-containing and cell-free subcutaneously implanted encapsulation devices.

Cell transplantation·2026
Same author

Antegrade persufflation of porcine kidneys improves renal function after warm ischemia.

Frontiers in transplantation·2024
Same author

Silicone rubber membrane devices permit islet culture at high density without adverse effects.

Frontiers in bioengineering and biotechnology·2024
Same author

Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets.

Frontiers in transplantation·2024
Same author

Accelerated absorption of regular insulin administered via a vascularizing permeable microchamber implanted subcutaneously in diabetic Rattus norvegicus.

PloS one·2023
Same author

Encapsulated Cells for the Treatment of Diabetes: Danger of Acute Hypoglycemia Following Injury?

Cell transplantation·2023

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • DNA checkpoints are critical for maintaining genomic integrity.
  • Dysfunctional checkpoints are implicated in cancer pathology.
  • Understanding checkpoint mechanisms is key to cancer treatment.

Purpose of the Study:

  • To review the genetic and molecular mechanisms of DNA checkpoint activation.
  • To identify major eukaryotic checkpoint proteins and their interactions.
  • To explore the link between checkpoint dysfunction and genomic instability.

Main Methods:

  • Literature review of genetic and molecular mechanisms.
  • Identification and discussion of conserved eukaryotic checkpoint proteins.
  • Analysis of checkpoint activation signals and repair pathways.

Related Experiment Videos

Main Results:

  • Detailed mechanisms of checkpoint activation by various DNA damages.
  • Elucidation of checkpoint protein interactions across cell cycle phases.
  • Connection between checkpoint proteins, DNA repair, and cell cycle arrest.

Conclusions:

  • DNA checkpoints are essential for preventing genomic instability.
  • Mutations in checkpoint genes contribute to cancer development.
  • Further research into checkpoint proteins may yield novel cancer therapies.