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Updated: Sep 28, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

[Anticoagulation in the treatment of sepsis. Correction of microcirculation: a new approach manipulating endothelial

P Kujath1, R Bouchard, H Shekarriz

  • 1Klinik für Chirurgie, Universitätsklinikum Lübeck, Germany.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|November 14, 2002
PubMed

The correction of coagulation disorders is only one aspect in the treatment of severe sepsis. The metabolic changes caused by sepsis are complex. They include the interactions of hundreds of plasma proteins. The system works in balanced patterns of agonists and antagonists, not allowing a preference for single substances. The endothelial cell plays a key role in multiple defence functions in sepsis. Thus, future research in sepsis has to focus on the manipulation of endothelial cell function.

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