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DNA minor groove hydration probed with 4'-alkylated thymidines
Ilka Detmer1, Daniel Summerer, Andreas Marx
1Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany.
Abstract:
Employing modified oligonucleotides that are 4'-alkylated site-specifically we investigated the involvement of DNA minor groove hydration on DNA duplex stability and helix conformation.