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Updated: Aug 12, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
EuII-cryptate with optimal water exchange and electronic relaxation: a synthon for potential pO2 responsive
László Burai1, Rosario Scopelliti, Eva Tóth
1Ecole Polytechnique Fédérale de Lausanne, 1CMB, BCH, Lausanne, Switzerland.
Abstract:
The cryptate [EuII(2.2.2)(H2O)2]2+ displays several interesting features with respect to pO2 responsive MRI contrast agent applications: it is relatively stable against oxidation, it has two inner sphere water molecules, and the water exchange and electron spin relaxation rates are in the optimal range to attain high proton relaxivities, provided the rotation is also optimized.
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