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Modification of post-PKS tailoring steps through combinatorial biosynthesis
Uwe Rix1, Carsten Fischer, Lily L Remsing
1Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.
Natural Product Reports
|November 15, 2002
Abstract:
This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases. ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.