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The international bone marrow transplant registry.
International Journal of Hematology
|November 15, 2002
Summary
Hematopoietic stem cell transplants, first performed in 1968, treat immune deficiencies and other diseases. Global transplant numbers are rising due to improved efficacy, donor availability, and supportive care.
Area of Science:
- Hematology
- Immunology
- Transplant Medicine
Background:
- The first hematopoietic stem cell transplants (HSCT) occurred in 1968 for congenital immune deficiencies.
- Since then, HSCT has become a vital treatment for numerous malignant and non-malignant diseases.
Purpose of the Study:
- To provide an overview of the historical development and current status of hematopoietic stem cell transplantation.
- To highlight the factors contributing to the increasing use and improved outcomes of HSCT.
Main Methods:
- Review of historical data and current estimates of HSCT procedures worldwide.
- Analysis of factors influencing the growth and success rates of HSCT.
Main Results:
- Approximately 50,000 HSCT procedures are performed annually worldwide, with a 10-15% annual growth rate.
- Autologous HSCT accounts for two-thirds of procedures, often using peripheral blood stem cells.
- Allogeneic HSCT, frequently from HLA-identical siblings using bone marrow, comprises the remainder.
Conclusions:
- Hematopoietic stem cell transplantation has evolved significantly since its inception.
- Improvements in efficacy, patient selection, donor matching, cell collection, and supportive care are driving the increasing utilization and success of HSCT.