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Updated: Jul 27, 2026

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Published on: April 11, 2017
Synthesis of leucascandrolide A via a spontaneous macrolactolization
Ying Wang1, Jelena Janjic, Sergey A Kozmin
1Department of Chemistry, University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.
Abstract:
We have developed a concise, convergent, and stereocontrolled synthesis of (+/-)-leucascandrolide A (18 steps from commercially available precursors), featuring a complete relay of the initial stereochemical information via a series of diastereoselective transformations. Spontaneous macrolactolization discovered during this synthetic exercise has provided unprecedented access to this macrolide and demonstrated the possibility of accessing even large-ring systems in a highly controlled and efficient manner.
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